Insulin Administration Acutely Decreases Vaspin Serum Concentrations in Humans

Insulin Administration Acutely Decreases Vaspin Serum Concentrations in Humans

It has been hypothesized that insulin might mediate meal-related diurnal variation in vaspin serum concentrations. We therefore investigated whether insulin affects serum vaspin levels in humans. Vaspin serum concentrations were determined by ELISA in 10 healthy individuals, who underwent an insulin tolerance test (ITT) for the evaluation of pituitary ACTH and growth hormone reserve. The ITTs w...

Serum vaspin concentrations in human obesity and type 2 diabetes.

OBJECTIVE Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the regulation of vaspin serum concentrations in human obesity and type 2 diabete...

Serum vaspin concentrations in relation to insulin sensitivity following RYGB-induced weight loss.

BACKGROUND Recently, vaspin was identified as a novel adipokine with insulin-sensitizing effects that might be implicated in endogenous glucose regulation. Our objective was to evaluate the impact of acute weight loss and metabolic changes on serum vaspin concentrations in morbidly obese subjects following laparoscopic Roux-en-Y gastric bypass (RYGB) surgery. METHODS Longitudinal, clinical in...

Arterial stiffness acutely decreases after whole-body vibration in humans.

BACKGROUND Increased arterial stiffness is a well-established cardiovascular risk factor. Mechanical stimuli to artery, such as compression, elicit vasodilation and acutely decrease arterial stiffness. As whole-body vibration (WBV)-induced oscillation is propagated at least to lumbar spine, WBV mechanically stimulates abdominal and leg arteries and may decrease arterial stiffness. WBV is feasib...

Circulating vaspin is unrelated to insulin sensitivity in a cohort of non-diabetic humans Short running title: serum vaspin and insulin sensitivity